Nrf2 Regulates the Expression of CYP2D6 by Inhibiting the Activity of Krüppel-Like Factor 9 (KLF9).

Ferbian Milas Siswanto, Rita Dewi Firmasyah,Maria Dara Novi Handayani,Ami Oguro,Susumu Imaoka

Current drug metabolism（2023）

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摘要

Our work revealed the inhibitory role of Nrf2 in regulating CYP2D6 expression. Moreover, Nrf2- dependent regulation of CYP2D6 can be used as a prognostic factor and therapeutic strategy in PD and liver cancer.

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