Deep learning techniques in PET/CT imaging: A comprehensive review from sinogram to image space

Positron emission tomography/computed tomography (PET/CT) is increasingly used in oncology, neurology, cardiology, and emerging medical fields. The success stems from the cohesive information that hybrid PET/CT imaging offers, surpassing the capabilities of individual modalities when used in isolation for different malig-nancies. However, manual image interpretation requires extensive disease-specific knowledge, and it is a time-consuming aspect of physicians' daily routines. Deep learning algorithms, akin to a practitioner during training, extract knowledge from images to facilitate the diagnosis process by detecting symptoms and enhancing images. This acquired knowledge aids in supporting the diagnosis process through symptom detection and image enhancement. The available review papers on PET/CT imaging have a drawback as they either included addi-tional modalities or examined various types of AI applications. However, there has been a lack of comprehensive investigation specifically focused on the highly specific use of AI, and deep learning, on PET/CT images. This review aims to fill that gap by investigating the characteristics of approaches used in papers that employed deep learning for PET/CT imaging. Within the review, we identified 99 studies published between 2017 and 2022 that applied deep learning to PET/CT images. We also identified the best pre-processing algorithms and the most effective deep learning models reported for PET/CT while highlighting the current limitations. Our review underscores the potential of deep learning (DL) in PET/CT imaging, with successful applications in lesion detection, tumor segmentation, and disease classification in both sinogram and image spaces. Common and specific pre-processing techniques are also discussed. DL algorithms excel at extracting meaningful features, and enhancing accuracy and efficiency in diagnosis. However, limitations arise from the scarcity of annotated datasets and challenges in explainability and uncertainty. Recent DL models, such as attention-based models, generative models, multi-modal models, graph convolutional networks, and transformers, are promising for improving PET/CT studies. Additionally, radiomics has garnered attention for tumor classification and predicting patient outcomes. Ongoing research is crucial to explore new applications and improve the accuracy of DL models in this rapidly evolving field.