Xenobiotic Exposure and Migraine-Associated Signaling: A Multimethod Experimental Study Exploring Cellular Assays in Combination with Ex Vivo and In Vivo Mouse Models.

Rikke H Rasmussen,Sarah L Christensen,Kirstine Calloe,Brian Skriver Nielsen,Anders Rehfeld,Thomas E Taylor-Clark,Kristian A Haanes,Olivier Taboureau,Karine Audouze,Dan A Klaerke,Jes Olesen,David M Kristensen

Environmental health perspectives（2023）

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摘要

Here we show that multiple environmental pollutants interact with the TRPA1-CGRP migraine pain pathway. The data provide valuable insights into how environmental chemicals can interact with neurobiology and provide a potential mechanism for putative increases in migraine prevalence over the last decades. https://doi.org/10.1289/EHP12413.

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