Integrin-dependent recruitment of Src to ROS-producing endosomes in osteoarthritic cartilage
Science signaling(2023)
摘要
Fibronectin (FN) fragments stimulate catabolic signaling, and, by binding to integrins, they induce chondrocytes to increase the production of matrix metalloproteinases, including MMP-13. In this issue of Science Signaling, Miao et al. reveal that internalization of a FN fragment, but not intact FN, by alpha 5 beta 1 integrin results in the formation of ROS-producing endosomes (redoxosomes) through which chondrocytes detect and respond to damaged matrix by producing more MMP-13.
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关键词
endosomes,src,integrin-dependent,ros-producing
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