The main bioactive compound of Panax notoginseng, notoginsenoside R1, alleviates pulmonary fibrosis via MBD2/SHIP and STAT3 pathway

Juan Wang, Yuwen Fang,Yongchun Zhou,Qin Chen,Jie Li,Yaxi Du,Xiuming Cui,Yuan Qu,Feng Ge

Journal of Functional Foods（2023）

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摘要

•Notoginsenoside R1 is the main bioactive compound of Panax notoginseng.•Pulmonary fibrosis is attenuated by notoginsenoside R1 in mice.•Notoginsenoside R1 inhibits the proliferation of collagen fibers in lung tissues.•MBD2/SHIP pathway plays a key role during the alleviation of pulmonary fibrosis.

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关键词

Panax notoginseng,Notoginsenoside R1,Pulmonary fibrosis,Methyl-CpG binding domain 2

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