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A Mechanistic Study on the Tolerance of PAM Distal End Mismatch by SpCas9

Dhritiman Dey,Rudra Chakravarti,Oindrila Bhattacharjee,Satyabrata Majumder,Dwaipayan Chaudhuri,Kazi Tawsif Ahmed, Dipanjan Roy,Bireswar Bhattacharya, Mansi Arya,Anupam Gautam,Rajveer Singh,Rahul Gupta,Velayutham Ravichandiran,Dhrubajyoti Chattopadhyay,Abhrajyoti Ghosh,Kalyan Giri,Syamal Roy,Dipanjan Ghosh

JOURNAL OF BIOLOGICAL CHEMISTRY（2024）

Cited 0|Views12
Key words
CRISPR-Cas9,RMSD,Off-target effect,mismatch tolerance,DNA-RNA conformational stability,PAM distal end
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