B4GALNT1 promotes hepatocellular carcinoma stemness and progression via integrin α2β1-mediated FAK and AKT activation

Yao Tang,Zhijie Xu, Fuyuan Xu,Juan Ye,Jianxu Chen,Jianzhong He,Yingchun Chen, Chunhui Qi,Hongbin Huang, Ruiyang Liu,Hong Shan,Fei Xiao

JHEP Reports（2023）

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摘要

•B4GALNT1 promotes HCC stemness, proliferation, invasion, migration, EMT and growth.•Elevated B4GALNT1 predicts poor prognosis in patients with HCC.•B4GALNT1 promotes HCC stemness and progression by regulating the integrin α2β1/FAK/PI3K/AKT axis.•Ophiopogonin D could be a potential therapeutic drug for patients with HCC.

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关键词

hepatocellular carcinoma stemness,hepatocellular carcinoma,integrin,akt activation

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