Ganoderma lucidum polysaccharides associated with 5-Fluorouracil impair OSCC tumorigenesis in vitro

Marcela Rodrigues de Camargo,Kelly Karina Inacio, Talita Fonseca Frazon,Nádia Ghinelli Amôr, Lígia Espoliar Corrêa, Flavia Cristina Costa,Emmanuelle Nascimento Quagliato,Camila Oliveira Rodini,Vanessa Soares Lara

Pharmacological Research - Modern Chinese Medicine（2023）

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摘要

•Ganoderma lucidum polysaccharides improves 5-Fluorouracil effectiveness on CSC.•Chemotherapy drug effect can be improved by GLPS.•Cancer stem cells can be sensitized using GLPS associated with chemotherapy.•Ganoderma lucidum polysaccharides can reduce the 5-FU doses in vitro.

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关键词

Ganoderma lucidum,Polysaccharides,5-fluorouracil,Cancer stem cells,HNSCC

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