Initial public health response and interim clinical guidance for the 2019 novel coronavirus outbreak — United States, December 31, 2019–February 4, 2020

This article summarizes what is currently known about the 2019 novel coronavirus and offers interim guidance. This article summarizes what is currently known about the 2019 novel coronavirus and offers interim guidance. On December 31, 2019, Chinese health officials reported a cluster of cases of acute respiratory illness in persons associated with the Hunan seafood and animal market in the city of Wuhan, Hubei Province, in central China. On January 7, 2020, Chinese health officials confirmed that a novel coronavirus (2019-nCoV) was associated with this initial cluster.1World Health OrganizationNovel coronavirus (2019-nCoV). Situation report 1.. World Health Organization, Geneva, Switzerland2020Google Scholar As of February 4, 2020, a total of 20,471 confirmed cases, including 2,788 (13.6%) with severe illness,* and 425 deaths (2.1%) had been reported by the National Health Commission of China.2World Health OrganizationNovel coronavirus (2019-nCoV). Situation report 15. World Health Organization, Geneva, Switzerland2020Google Scholar Cases have also been reported in 26 locations outside of mainland China, including documentation of some person-to-person transmission and one death.2World Health OrganizationNovel coronavirus (2019-nCoV). Situation report 15. World Health Organization, Geneva, Switzerland2020Google Scholar As of February 4, 11 cases had been reported in the United States. On January 30, the World Health Organization (WHO) Director-General declared that the 2019-nCoV outbreak constitutes a Public Health Emergency of International Concern.† On January 31, the US Department of Health and Human Services (HHS) Secretary declared a US public health emergency to respond to 2019-nCoV.§ Also on January 31, the president of the United States signed a “Proclamation on Suspension of Entry as Immigrants and Nonimmigrants of Persons who Pose a Risk of Transmitting 2019 Novel Coronavirus,” which limits entry into the United States of persons who traveled to mainland China to US citizens and lawful permanent residents and their families.3Office of the PresidentProclamation on suspension of entry as immigrants and nonimmigrants of persons who pose a risk of transmitting 2019 novel coronavirus. Office of the President, Washington, DC2020Google Scholar CDC, multiple other federal agencies, state and local health departments, and other partners are implementing aggressive measures to slow transmission of 2019-nCoV in the United States.4Holloway R Rasmussen SA Zaza S Cox NJ Jernigan DB. Updated preparedness and response framework for influenza pandemics.MMWR Recomm Rep. 2014; 63Google Scholar,5Reed C Biggerstaff M Finelli L et al.Novel framework for assessing epidemiologic effects of influenza epidemics and pandemics.Emerg Infect Dis. 2013; 19: 85-91Crossref PubMed Scopus (82) Google Scholar These measures require the identification of cases and their contacts in the United States and the appropriate assessment and care of travelers arriving from mainland China to the United States. These measures are being implemented in anticipation of additional 2019-nCoV cases in the United States. Although these measures might not prevent the eventual establishment of ongoing, widespread transmission of the virus in the United States, they are being implemented to 1) slow the spread of illness; 2) provide time to better prepare health care systems and the general public to be ready if widespread transmission with substantial associated illness occurs; and 3) better characterize 2019-nCoV infection to guide public health recommendations and the development of medical countermeasures including diagnostics, therapeutics, and vaccines. Public health authorities are monitoring the situation closely. As more is learned about this novel virus and this outbreak, CDC will rapidly incorporate new knowledge into guidance for action by CDC and state and local health departments. Some coronaviruses, such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS), are the result of human-animal interactions. Preliminary investigation of 2019-nCoV also suggests a zoonotic origin,6Lu R, Zhao X, Li J, et al. Genomic characterization and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 2020. Epub January 29, 2020.Google Scholar but the exact origin has not yet been determined. Person-to-person spread is evident;7Li Q, Guan X, Wu P, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med. 2020. Epub January 29, 2020.Google Scholar however, how easily the virus is transmitted between persons is currently unclear. 2019-nCoV is similar to coronaviruses that cause MERS and SARS, which are transmitted mainly by respiratory droplets. Signs and symptoms of patients with confirmed 2019-nCoV infection include fever, cough, and shortness of breath.8Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020. Epub January 30, 2020.Google Scholar Based on the incubation period of illness from MERS and SARS coronaviruses, CDC believes that symptoms of 2019-nCoV infection occur within 2 to 14 days following infection. Preliminary information suggests that older adults and persons with underlying health conditions or compromised immune systems might be at higher risk for severe illness from this virus9Hunag C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020. Epub January 24, 2020.Google Scholar; however, many characteristics of this novel coronavirus and how it might affect individual persons and potentially vulnerable population subgroups, such as the elderly or those with chronic health conditions, remain unclear. On January 21, 2020, the first person in the United States with diagnosed 2019-nCoV infection was reported. As of February 4, a total of 293 persons from 36 states, the District of Columbia, and the US Virgin Islands were under investigation based on current patient under investigation (PUI) definitions,¶ and also included those being evaluated because they are close contacts. Of these PUIs, 11 patients have confirmed 2019-nCoV infection using a real-time reverse transcription–polymerase chain reaction (RT-PCR) assay developed by CDC. These 11 cases were diagnosed in the following states: Arizona (one), California (six), Illinois (two), Massachusetts (one), and Washington (one) (Table 1). Nine cases were in travelers from Wuhan. Eight of these nine cases were identified as a result of patients seeking clinical care for symptoms and clinicians connecting with the appropriate public health systems. Two cases (one each in California and Illinois) occurred in close contacts of two confirmed cases and were diagnosed as part of routine monitoring of case contacts. All patients are being monitored closely for progressing illness. No deaths have been reported in the United States.TABLE 1Characteristics of initial 2019 novel coronavirus cases (N = 11) — United States, January 21–February 4, 2020CaseStateApproximate age (yrs)SexPlace of exposureDate laboratory confirmation announced1Washington30sMWuhan1/21/20202Illinois60sFWuhan1/24/20203Arizona20sMWuhan1/26/20204California30sMWuhan1/27/20205California50sMWuhan1/27/20206Illinois60sMHousehold Illinois1/30/20207California40sMWuhan1/31/20208Massachusetts20sMWuhan2/01/20209California50sFWuhan2/02/202010California50sMWuhan2/02/202011California50sFHousehold California2/02/2020Abbreviations: F, female; M, male. Open table in a new tab Abbreviations: F, female; M, male. CDC established a 2019-nCoV Incident Management Structure on January 7, 2020. On January 21, CDC activated its Emergency Operations Center to optimize coordination for domestic and international 2019-nCoV response efforts. To date, CDC has deployed teams to the US jurisdictions with cases to assist with epidemiologic investigation and to work closely with state and local partners to identify and monitor close contacts and better understand the spectrum of illness, transmission, and virulence associated with this novel virus. Information learned from these investigations will help inform response actions. CDC has closely monitored the global impact of this virus with staff members positioned in CDC offices around the world, including mainland China, and in coordination with other countries and WHO. This coordination has included deploying CDC staff members to work with WHO and providing active support to CDC offices in affected countries. In addition, CDC in response to the escalating risks of travel from China has issued a series of Travelers’ Health Notices for both Wuhan and the rest of China regarding the 2019-nCoV outbreak. On January 27, CDC issued a Level 3 travel notice for travelers to avoid all nonessential travel to mainland China.**** US quarantine stations, located at 18 major US ports of entry, are part of a comprehensive regulatory system authorized under section 361 of the Public Health Service Act (42 US Code Section 264), that limits the introduction of infectious diseases into the United States to prevent their spread. On January 17, consistent with existing communicable disease response protocols, CDC Quarantine staff members instituted enhanced entry screening of travelers on direct and connecting flights from Wuhan, China, arriving at three major US airports: Los Angeles (LAX), New York City (JFK), and San Francisco (SFO),†† which then expanded to include travelers arriving in Atlanta (ATL) and Chicago (ORD). These five airports together receive approximately 85% of all air travelers from Wuhan, China, to the United States. US Customs and Border Protection officers identified travelers arriving from Wuhan and referred them to CDC for health screening.§§ Any traveler from Wuhan with signs or symptoms of illness (eg, fever, cough, or difficulty breathing) received a more comprehensive public health assessment performed by CDC public health and medical officers.¶¶ All travelers from Wuhan were also provided CDC’s Travel Health Alert Notice (T-HAN)***** that advised them to monitor their health for 14 days and described recommended actions to take if relevant symptoms develop. As of February 1, 2020, a total of 3,099 persons on 437 flights were screened; five symptomatic travelers were referred by CDC to local health care providers for further medical evaluation, and one of these persons tested positive for 2019-nCoV.SummaryWhat is already known about this topic?In December 2019, an outbreak of acute respiratory illness caused by a novel coronavirus (2019-nCoV) was detected in mainland China. Cases have been reported in 26 additional locations, including the United States.What is added by this report?Nine of the first 11 US 2019-nCoV patients were exposed in Wuhan, China. CDC expects more US cases.What are the implications for public health practice?CDC, multiple other federal agencies, state and local health departments, and other partners are implementing aggressive measures to substantially slow US transmission of 2019-nCoV, including identification of US cases and contacts and managing travelers arriving from mainland China to the United States. Interim guidance is available at https://www.cdc.gov/coronavirus/index.html and will be updated as more information becomes available. What is already known about this topic? In December 2019, an outbreak of acute respiratory illness caused by a novel coronavirus (2019-nCoV) was detected in mainland China. Cases have been reported in 26 additional locations, including the United States. What is added by this report? Nine of the first 11 US 2019-nCoV patients were exposed in Wuhan, China. CDC expects more US cases. What are the implications for public health practice? CDC, multiple other federal agencies, state and local health departments, and other partners are implementing aggressive measures to substantially slow US transmission of 2019-nCoV, including identification of US cases and contacts and managing travelers arriving from mainland China to the United States. Interim guidance is available at https://www.cdc.gov/coronavirus/index.html and will be updated as more information becomes available. On January 24, 2020, travel bans began to be instituted by the Chinese government, resulting in restricted travel in and out of Hubei Province, including the city of Wuhan, and fewer travelers undergoing entry screening in the United States. In response to the escalating risks associated with travel from mainland China, on January 31, 2020, the Presidential Proclamation further refined the border health strategy to temporarily suspend entry, undergo additional screening, or possible quarantine for individuals that have visited China (excluding Hong Kong, Macau, and Taiwan) in the past 14 days. These enhanced entry screening efforts are taking place at 11 airports at which all air travelers from China are being directed. Chinese health officials posted the full 2019-nCoV genome sequence on January 10, 2020, to inform the development of specific diagnostic tests for this emergent coronavirus.1World Health OrganizationNovel coronavirus (2019-nCoV). Situation report 1.. World Health Organization, Geneva, Switzerland2020Google Scholar Within a week, CDC developed a Clinical Laboratory Improvement Amendments–approved real-time RT-PCR test that can diagnose 2019-nCoV respiratory samples from clinical specimens. On January 24, CDC publicly posted the assay protocol for this test (https://www.cdc.gov/coronavirus/2019-nCoV/lab/index.html). On January 4, 2020, the Food and Drug Administration issued an Emergency Use Authorization to enable emergency use of CDC’s 2019-nCoV Real-Time RT-PCR Diagnostic Panel. To date, this test has been limited to use at CDC laboratories. This authorization allows the use of the test at any CDC-qualified lab across the country. CDC is working closely with FDA and public health partners, including the American Public Health Laboratories, to rapidly share these tests domestically and internationally through CDC’s International Reagent Resource (https://www.internationalreagentresource.org/). In addition, CDC uploaded the genome of the virus from the first reported cases in the United States to GenBank, the National Institutes of Health genetic sequence database of publicly available DNA sequences (https://www.ncbi.nlm.nih.gov/genbank/). CDC also is growing the virus in cell culture, which is necessary for further studies, including for additional genetic characterization. Once isolated, the virus will be made available through BEI Resources (https://www.beiresources.org/) to assist research efforts. Additional information about 2019-nCoV is needed to better understand transmission, disease severity, and risk to the general population. Although CDC and partners are actively learning about 2019-nCoV, initial CDC guidance is based on guidance for management and prevention of respiratory illnesses including influenza, MERS, and SARS. No vaccine or specific treatment for 2019-nCoV infection is currently available. At present, medical care for patients with 2019-nCoV is supportive. On January 31, CDC published its third Health Advisory with interim guidance for clinicians and public health practitioners.††† In addition, CDC issued a Clinical Action Alert through its Clinician Outreach and Communication Activity network on January 31.§§§ Interim guidance for health care professionals is available at https://www.cdc.gov/coronavirus/2019-nCoV/hcp/clinical-criteria.html. Health care providers should identify patients who might have been exposed and who have signs or symptoms related to 2019-nCoV infection, isolate these patients, and inform public health departments. This includes obtaining a detailed travel history for patients being evaluated with fever and lower respiratory tract illness. Criteria to guide evaluation and testing of PUIs for 2019-nCoV include 1) fever or signs or symptoms of lower respiratory tract illness (eg, cough or shortness of breath) in any person, including health care workers, who has had close contact¶¶¶ with a patient with laboratory-confirmed 2019-nCoV infection within 14 days of symptom onset; 2) fever and signs or symptoms of lower respiratory tract illness (eg, cough or shortness of breath) in any person with a history of travel from Hubei Province, China, within 14 days of symptom onset; or 3) fever and signs or symptoms of lower respiratory tract illness (eg, cough or shortness of breath) requiring hospitalization in any person with a history of travel from mainland China within 14 days of symptom onset. Additional nonhospitalized PUIs may be tested based on consultation with state and local public health officials. Clinicians should evaluate PUIs for other possible causes of illness (eg, influenza and respiratory syncytial virus) as clinically indicated. CDC currently recommends a cautious approach to the examination of PUIs. These patients should be asked to wear a surgical mask as soon as they are identified, and directed to a separate area, if possible, separated by at least 6 ft (2 m) from other persons. Patients should be evaluated in a private room with the door closed, ideally an airborne infection isolation room, if available. Health care personnel entering the room should use standard precautions, contact precautions, airborne precautions, and eye protection (eg, goggles or a face shield). Clinicians should immediately notify the health care facility’s infection control personnel and local health department. The health department will determine whether the patient needs to be considered a PUI for 2019-nCoV and be tested for infection. If directed by the health department, to increase the likelihood of detecting 2019-nCoV infection, CDC recommends collecting and testing both upper and lower respiratory tract specimens.****** Additional specimen types (eg, stool or urine) may be collected and stored. Specimens should be collected as soon as possible once a PUI is identified regardless of time since symptom onset. For persons who might have 2019-nCoV infection and their close contacts, information and guidance on how to reduce the risk for transmitting and acquiring infection is available at https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidance-prevent-spread.html. Close contacts should immediately call their health care providers if they develop symptoms. In addition, CDC is working closely with state and local health partners to develop and disseminate information to the public on general prevention of respiratory illness, including the 2019-nCoV. This includes everyday preventive actions such as washing your hands, covering your cough, and staying home when you are ill. Additional information and resources for this outbreak are available on the CDC website (https://www.cdc. gov/coronavirus/2019-ncov/index.html). The 2019-nCoV has impacted multiple countries, caused severe illness, and sustained person-to-person transmission making it a concerning and serious public health threat. It is unclear how this virus will impact the US over time. For the general population, who are unlikely to be exposed to this virus at the current time, the immediate health risk from 2019-nCoV is considered low. CDC, multiple other federal agencies, state and local health departments, and other partners are implementing aggressive measures to slow US transmission of 2019-nCoV.4Holloway R Rasmussen SA Zaza S Cox NJ Jernigan DB. Updated preparedness and response framework for influenza pandemics.MMWR Recomm Rep. 2014; 63Google Scholar,5Reed C Biggerstaff M Finelli L et al.Novel framework for assessing epidemiologic effects of influenza epidemics and pandemics.Emerg Infect Dis. 2013; 19: 85-91Crossref PubMed Scopus (82) Google Scholar These measures require the identification of cases and contacts in the United States and the effective management of the estimated 14,000 travelers arriving from mainland China to the United States each day.3Office of the PresidentProclamation on suspension of entry as immigrants and nonimmigrants of persons who pose a risk of transmitting 2019 novel coronavirus. Office of the President, Washington, DC2020Google Scholar These measures are being implemented based on the assumption that there will be more US 2019-nCoV cases occurring with potential chains of transmission, with the understanding that these measures might not prevent the eventual establishment of ongoing, widespread transmission of the virus in the United States. It is important for public health agencies, health care providers, and the public to be aware of this new 2019-nCoV so that coordinated, timely, and effective actions can help prevent additional cases or poor health outcomes. The critical role that the US health care system plays in halting or significantly slowing US transmission of 2019-nCoV is already evident: eight of the first 11 US cases were detected by clinicians collaborating with public health to test persons at risk. The early recognition of cases in the United States reduces transmission risk and increases understanding of the virus, including its transmission and severity, to inform national and global response actions. 2019-nCoV symptoms are similar to those of influenza (eg, fever, cough, or sore throat), and the outbreak is occurring during a time of year when respiratory illnesses from influenza, respiratory syncytial virus, and other respiratory viruses are highly prevalent. To prevent influenza, all persons aged ≥ 6 months should receive an annual influenza vaccine, and vaccination is still available and effective in helping to prevent influenza.10Grohskopf LA Alyanak E Broder KR Walter EB Fry AM Jernigan DB. Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices—United States, 2019–20 influenza season.MMWR Recomm Rep. 2019; 68Google Scholar Reducing the number of persons in the United States with seasonal influenza will reduce possible confusion with 2019-nCoV infection and possible additional risk to patients with seasonal influenza. Public health authorities are monitoring the situation closely. As more is learned about this novel virus and this outbreak, CDC will rapidly incorporate new knowledge into guidance for action. Fatuma Abdirizak, National Center for Immunization and Respiratory Diseases, CDC; Glen Abedi, National Center for Immunization and Respiratory Diseases, CDC; Sharad Aggarwal, National Center for Immunization and Respiratory Diseases, CDC; Denise Albina, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Elizabeth Allen, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Lauren Andersen, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Jade Anderson, Center for Preparedness and Response, CDC; Megan Anderson, Center for Preparedness and Response, CDC; Tara Anderson, Center for State, Tribal, Local and Territorial Support, CDC; Kayla Anderson, National Center on Birth Defects and Developmental Disabilities, CDC; Ana Cecilia Bardossy, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Vaughn Barry, National Center for Injury Prevention and Control, CDC; Karlyn Beer, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Michael Bell, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Sherri Berger, Office of the Director, CDC; Joseph Bertulfo, Office of the Director, CDC; Holly Biggs, National Center for Immunization and Respiratory Diseases, CDC; Jennifer Bornemann, Office of the Director, CDC; Josh Bornstein, Office of the Director, CDC; Willie Bower, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Joseph Bresee, National Center for Immunization and Respiratory Diseases, CDC; Clive Brown, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Alicia Budd, National Center for Immunization and Respiratory Diseases, CDC; Jennifer Buigut, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Stephen Burke, National Center for Immunization and Respiratory Diseases, CDC; Rachel Burke, National Center for Immunization and Respiratory Diseases, CDC; Erin Burns, National Center for Immunization and Respiratory Diseases, CDC; Jay Butler, Office of the Deputy Director of Infectious Disease, CDC; Russell Cantrell, Center for State, Tribal, Local and Territorial Support, CDC; Cristina Cardemil, National Center for Immunization and Respiratory Diseases, CDC; Jordan Cates, National Center for Immunization and Respiratory Diseases, CDC; Marty Cetron, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Kevin Chatham-Stephens, National Center on Birth Defects and Developmental Disabilities, CDC; Kevin Chatham-Stevens, National Center on Birth Defects and Developmental Disabilities, CDC; Nora Chea, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Bryan Christensen, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Victoria Chu, National Center for Immunization and Respiratory Diseases, CDC; Kevin Clarke, Center for Global Health, CDC; Angela Cleveland, National Center for Immunization and Respiratory Diseases, CDC; Nicole Cohen, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Max Cohen, Center for State, Tribal, Local and Territorial Support, CDC; Amanda Cohn, National Center for Immunization and Respiratory Diseases, CDC; Jennifer Collins, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Erin Conners, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Aaron Curns, National Center for Immunization and Respiratory Diseases, CDC; Rebecca Dahl, National Center for Immunization and Respiratory Diseases, CDC; Walter Daley, Center for Preparedness and Response, CDC; Vishal Dasari, Center for State, Tribal, Local and Territorial Support, CDC; Elizabeth Davlantes, Center for State, Tribal, Local and Territorial Support, CDC; Patrick Dawson, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Lisa Delaney, National Institute for Occupational Safety and Health, CDC; Matthew Donahue, Center for State, Tribal, Local and Territorial Support, CDC; Chad Dowell, National Institute for Occupational Safety and Health, CDC; Jonathan Dyal, National Center for Immunization and Respiratory Diseases, CDC; William Edens, National Center for Immunization and Respiratory Diseases, CDC; Rachel Eidex, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Lauren Epstein, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Mary Evans, National Center for Injury Prevention and Control, CDC; Ryan Fagan, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Kevin Farris, National Center for Immunization and Respiratory Diseases, CDC; Leora Feldstein, National Center for Immunization and Respiratory Diseases, CDC; LeAnne Fox, National Center for Immunization and Respiratory Diseases, CDC; Mark Frank, Center for Preparedness and Response, CDC; Brandi Freeman, National Center for Immunization and Respiratory Diseases, CDC; Alicia Fry, National Center for Immunization and Respiratory Diseases, CDC; James Fuller, Center for Global Health, CDC; Romeo Galang, National Center for Chronic Disease Prevention and Promotion, CDC; Sue Gerber, National Center for Immunization and Respiratory Diseases, CDC; Runa Gokhale, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Sue Goldstein, National Center for Immunization and Respiratory Diseases, CDC; Sue Gorman, Center for Preparedness and Response, CDC; William Gregg, National Center for Immunization and Respiratory Diseases, CDC; William Greim, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Steven Grube, Office of the Director, CDC; Aron Hall, National Center for Immunization and Respiratory Diseases, CDC; Amber Haynes, National Center for Immunization and Respiratory Diseases, CDC; Sherrasa Hill, National Center for Immunization and Respiratory Diseases, CDC; Jennifer Hornsby-Myers, National Institute for Occupational Safety and Health, CDC; Jennifer Hunter, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Christopher Ionta, National Center for Immunization and Respiratory Diseases, CDC; Cheryl Isenhour, National Center for Immunization and Respiratory Diseases, CDC; Max Jacobs, Center for State, Tribal, Local and Territorial Support, CDC; Kara Jacobs Slifka, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Daniel Jernigan, National Center for Immunization and Respiratory Diseases, CDC; Michael Jhung, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Jamie Jones-Wormley, Center for Preparedness and Response, CDC; Anita Kambhampati, National Center for Immunization and Respiratory Diseases, CDC; Shifaq Kamili, National Center for Immunization and Respiratory Diseases, CDC; Pamela Kennedy, National Center for Immunization and Respiratory Diseases, CDC; Charlotte Kent, Center for Surveillance Epidemiology and Laboratory Services, CDC; Marie Killerby, National Center for Immunization and Respiratory Diseases, CDC; Lindsay Kim, National Center for Immunization and Respiratory Diseases, CDC; Hannah Kirking, National Center for Immunization and Respiratory Diseases, CDC; Lisa Koonin, National Center for Immunization and Respiratory Diseases, CDC; Ram Koppaka, National Center for Immunization and Respiratory Diseases, CDC; Christine Kosmos, Center for Preparedness and Response, CDC; David Kuhar, National Center for Emerging and Zoonotic Infectious Diseases CDC; Wendi Kuhnert-Tallman, Deputy Director for Infectious Diseases, CDC; Stephanie Kujawski, National Center for Immunization and Respiratory Diseases CDC; Archana Kumar, National Center for Immunization and Respiratory Diseases, CDC; Alexander Landon, Office of the Director, CDC; Leslie Lee, National Center for Immunization and Respiratory Diseases, CDC; Jessica Leung, National Center for Immunization and Respiratory Diseases, CDC; Stephen Lindstrom, National Center for Immunization and Respiratory Diseases, CDC; Ruth Link-Gelles, National Center for Immunization and Respiratory Diseases, CDC; Joana Lively, National Center for Immunization and Respiratory Diseases, CDC; Xiaoyan Lu, National Center for Immunization and Respiratory Diseases, CDC; Brian Lynch, National Center for Immunization and Respiratory Diseases, CDC; Lakshmi Malapati, National Center for Immunization and Respiratory Diseases, CDC; Samantha Mandel, National Center for Immunization and Respiratory Diseases, CDC; Brian Manns, National Center for Immunization and Respiratory Diseases, CDC; Nina Marano, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Mariel Marlow, National Center for Immunization and Respiratory Diseases, CDC; Barbara Marston, Center for Global Health, CDC; Nancy McClung, National Center for Immunization and Respiratory Diseases, CDC; Liz McClure, Center for Global Health, CDC; Emily McDonald, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Oliva McGovern, National Center for Immunization and Respiratory Diseases, CDC; Nancy Messonnier, National Center for Immunization and Respiratory Diseases, CDC; Claire Midgley, National Center for Immunization and Respiratory Diseases, CDC; Danielle Moulia, National Center for Immunization and Respiratory Diseases, CDC; Janna Murray, National Center for Immunization and Respiratory Diseases, CDC; Kate Noelte, Center for Preparedness and Response, CDC; Michelle Noonan-Smith, Office of the Director, CDC; Kristen Nordlund, National Center for Immunization and Respiratory Diseases, CDC; Emily Norton, National Institute for Occupational Safety and Health, CDC; Sara Oliver, National Center for Immunization and Respiratory Diseases, CDC; Mark Pallansch, National Center for Immunization and Respiratory Diseases, CDC; Umesh Parashar, National Center for Immunization and Respiratory Diseases, CDC; Anita Patel, National Center for Immunization and Respiratory Diseases, CDC; Manisha Patel, National Center for Immunization and Respiratory Diseases, CDC; Kristen Pettrone, National Center for Health Statistics, CDC; Taran Pierce, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Harald Pietz, Center for Preparedness and Response, CDC; Satish Pillai, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Lewis Radonovich, National Institute for Occupational Safety and Health, CDC; Sarah Reagan-Steiner, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Amy Reel, National Center for Immunization and Respiratory Diseases, CDC; Heather Reese, National Center for Immunization and Respiratory Diseases, CDC; Brian Rha, National Center for Immunization and Respiratory Diseases, CDC; Philip Ricks, Center for Global Health, CDC; Melissa Rolfes, National Center for Immunization and Respiratory Diseases, CDC; Shahrokh Roohi, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Lauren Roper, National Center for Immunization and Respiratory Diseases, CDC; Lisa Rotz, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Janell Routh, National Center for Immunization and Respiratory Diseases, CDC; Senthil Kumar Sakthivel, National Center for Immunization and Respiratory Diseases, CDC; Luisa Sarmiento, National Institute for Occupational Safety and Health, CDC; Jessica Schindelar, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Eileen Schneider, National Center for Immunization and Respiratory Diseases, CDC; Anne Schuchat, Office of the Director, CDC; Sarah Scott, Center for State, Tribal, Local and Territorial Support, CDC; Varun Shetty, Center for State, Tribal, Local and Territorial Support, CDC; Caitlin Shockey, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Jill Shugart, National Institute for Occupational Safety and Health, CDC; Mark Stenger, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention CDC; Matthew Stuckey, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Brittany Sunshine, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Tamara Sykes, Office of the Director, CDC; Jonathan Trapp, Office of the Director, CDC; Timothy Uyeki, National Center for Immunization and Respiratory Diseases, CDC; Grace Vahey, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Amy Valderrama, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Julie Villanueva, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Tunicia Walker, Center for Preparedness and Response, CDC; Megan Wallace, National Center for Immunization and Respiratory Diseases, CDC; Lijuan Wang, National Center for Immunization and Respiratory Diseases, CDC; John Watson, National Center for Immunization and Respiratory Diseases, CDC; Angie Weber, National Institute for Occupational Safety and Health, CDC; Cindy Weinbaum, National Center for Immunization and Respiratory Diseases, CDC; William Weldon, National Center for Immunization and Respiratory Diseases, CDC; Caroline Westnedge, National Center for Immunization and Respiratory Diseases, CDC; Brett Whitaker, National Center for Immunization and Respiratory Diseases, CDC; Michael Whitaker, National Center for Immunization and Respiratory Diseases, CDC; Alcia Williams, Office of the Director, CDC; Holly Williams, Office of the Director, CDC; Ian Willams, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Karen Wong, Center for Surveillance, Epidemiology and Laboratory Services, CDC; Amy Xie, Center for State, Tribal, Local and Territorial Support, CDC; Anna Yousef, National Center for Immunization and Respiratory Diseases, CDC. Arizona Department of Health Services; Maricopa County Department of Public Health; California Department of Public Health; Los Angeles County Department of Public Health; Orange County Health Department; San Benito County Public Health Services Department; Santa Clara County Public Health Department; Illinois Department of Public Health; Chicago Department of Public Health; Cook County Department of Public Health; DuPage County Health Department; Massachusetts Department of Public Health; Washington State Department of Health; Snohomish Health District. All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. No potential conflicts of interest were disclosed. * Includes any of the following: dyspnea, respiratory rate > 30 breaths per minute, hypoxemia, or chest x-ray with multilobar infiltrates or > 50% progression of pulmonary infiltration within 24-48 hours per WHO. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200123-sitrep-3-2019-ncov.pdf. † https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov). § https://www.phe.gov/emergency/news/healthactions/phe/Pages/2019-nCoV.aspx. ¶ Criteria to guide evaluation and testing of patients under investigation for 2019-nCoV include 1) fever or signs or symptoms of lower respiratory tract illness (eg, cough or shortness of breath) in any person, including a health care worker, who has had close contact with a patient with laboratory-confirmed 2019-nCoV infection within 14 days of symptom onset; 2) fever and signs or symptoms of lower respiratory tract illness (eg, cough or shortness of breath) in any person with a history of travel from Hubei Province, China, within 14 days of symptom onset; or 3) fever and signs or symptoms of lower respiratory tract illness (eg, cough or shortness of breath) requiring hospitalization in any person with a history of travel from mainland China within 14 days of symptom onset. More information is available at https://emergency.cdc.gov/han/han00427.asp and https://emergency.cdc.gov/han/han00426.asp. ** https://wwwnc.cdc.gov/travel/notices/warning/novel-coronavirus-china. †† https://www.cdc.gov/media/releases/2020/p0117-coronavirus-screening.html. §§ CDC’s initial health screening includes a measurement of each traveler’s temperature with a handheld noncontact thermometer, observation of these travelers for visible signs of respiratory illness (eg, cough or difficulty breathing), and review of symptoms through a self-administered questionnaire. ¶¶ The more comprehensive public health assessment determines, based on the traveler’s illness and exposure, whether the traveler should be taken to a hospital for further medical evaluation and care, which might include testing for 2019-nCoV. *** https://www.cdc.gov/coronavirus/2019-ncov/travelers/communication-resources.html. ††† https://emergency.cdc.gov/han/han00427.asp. §§§ https://emergency.cdc.gov/coca/calls/2020/callinfo_013120.asp. ¶¶¶ Close contact is defined as 1) being within approximately 6 ft (2 m) of a 2019-nCoV patient for a prolonged period while not wearing recommended personal protective equipment (PPE) (eg, gowns, gloves, National Institute for Occupational Safety and Health–certified disposable N95 respirator, and eye protection); close contact can occur while caring for, living with, visiting, or sharing a health care waiting area or room with a 2019-nCoV patient; or 2) having direct contact with infectious secretions of a 2019-nCoV patient (eg, being coughed on) while not wearing recommended PPE. **** https://www.cdc.gov/coronavirus/2019-nCoV/lab/guidelines-clinical-specimens.html.