Development of a human glioblastoma model using humanized DRAG mice for immunotherapy.

Rashmi Srivastava,Alireza Labani-Motlagh,Apeng Chen,Jose Alejandro Bohorquez,Bin Qin,Meghana Dodda,Fan Yang,Danish Ansari,Sahil Patel,Honglong Ji,Scott Trasti,Yapeng Chao,Yash Patel,Han Zou,Baoli Hu,Guohua Yi

Antibody therapeutics（2023）

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摘要

Glioblastoma (GBM) is the most common and lethal primary brain tumor. The development of alternative humanized mouse models with fully functional human immune cells will potentially accelerate the progress of GBM immunotherapy. We successfully generated humanized DRAG (NOD.Rag1KO.IL2RγcKO) mouse model by transplantation of human DR4 ++++++++++--+-+

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human glioblastoma model,drag mice

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