GCN2 is required to maintain core body temperature in mice during acute cold.

Jordan L Levy,Emily T. Mirek,Esther Rodrı́guez,Brian Zalma,Jeffrey M. Burns,William Jonsson,Harini Sampath,Kirk A. Staschke,Ronald C. Wek,Tracy G. Anthony

American Journal of Physiology-endocrinology and Metabolism（2023）

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摘要

This paper details the discovery that GCN2 activation is required in both male and female mice to maintain core body temperature during acute cold exposure. The results point to a novel role for GCN2 in supporting adaptive thermogenesis via amino acid transport and actomyosin mechanics in brown adipose tissue.

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关键词

core body temperature,gcn2,acute cold

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