Background free in vivo²⁹Si MR imaging with hyperpolarized PEGylated silicon nanoparticles

This study demonstrated the potential of 50 nm PEGylated Si NPs for high-resolution in vivo Si-29 MR imaging, emphasizing their biocompatibility and water dispersibility. The acquisition of in vivo Si MR images using the lowest reported dose after subcutaneous and intraperitoneal administration opens new avenues for future Si-29 MR studies.