A practical regeneration approach and model simulation for poisoned-resin recycle to selectively detoxify acetic acid-like bio-inhibitors in acidic lignocellulose hydrolysate

•A practical and economical approach was used to regenerate poisoned-resin.•Kinetic and thermodynamic modeling of regeneration processes was investigated.•The mechanism of resin regeneration was preliminarily investigated.•Resin was efficiently used four times in lignocellulose hydrolysate utilization.