Corrigendum to “SIRT5 rs12216101 T>G variant is associated with liver damage and mitochondrial dysfunction in patients with non-alcoholic fatty liver disease” [J Hepatol 80 (2024) 10-19]

Federico Salomone,Rosaria Maria Pipitone,Miriam Longo,Francesco Malvestiti,Angela Maria Amorini,Alfio Distefano,Elia Casirati,Ester Ciociola,Nunzio Iraci,Loredana Leggio,Rossella Zito,Nunzio Vicario,Concetta Saoca,Ville Männistö,Jussi Pihlajamäki,Sami Qadri, Hannele Yki-Järvinen,Stefano Romeo,Grazia Pennisi,Daniela Cabibi

Journal of Hepatology（2024）

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摘要

•Mitochondrial dysfunction plays a key role in NAFLD onset and progression.•SIRT5 is crucial in the regulation of mitochondrial processes.•SIRT5 rs12216101 T>G SNP associates with higher disease severity in patients with NAFLD.•SIRT5 rs12216101 T>G variant induces upregulation of OXPHOS in patients with NAFLD.•SIRT5 rs12216101 T>G variant promotes oxidative stress in patients with NAFLD.

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关键词

NAFLD,NASH,SIRT5,SNP,Mitochondrial function,Oxidative stress,Fibrosis

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