Visible-light-promoted photoredox-catalyzed N-aminoalkylation of quinazolinones with simple alkylamide

A metal free visible-light promoted direct coupling of simple alkylamides and quinazolinones via C-H bond oxidative cross-coupling to access highly functionalized N-aminoalkyl quinazolinones was reported. This protocol serves as a straightforward strategy for N-aminoalkylation transformation of quinazolinones employing tert- butyl peroxybenzoate as oxidant under visible-light irradiation condition. This process features metal-free, mild reaction conditions and the tolerance for a wide range of functional groups. Synthetically important and highly functionalized N-aminoalkyl quinazolinones were afforded with moderate to good yields and high chemoselectivity.