Anthocleista vogelii (Planch) stem bark ethanol extract prevents inflammatory and pain phenotypes in experimental rodent models by modulating oxido-inflammatory mediators

•AVSBE reduces pain-like behaviors like writhing, paw licking and, pain reaction time while also exhibiting anti-inflammatory properties by reducing paw size in animal models•AVSBE reduces oxido-nitrosative stress and inflammatory mediators in animals•AVSBE has a high safety profile, with an LD50 greater than 5000 mg/kg, and does not cause stomach ulceration in animals•The beneficial effects of AVSBE may be attributed to its bioactive metabolites such as eicosanoic, octadecatrienoic, linoleic, palmitoleic, and 9,12-octadecanoic acids, phytol, and so on