Inhibition of α2,6-sialyltransferase relieves symptoms of ulcerative colitis by regulating Th17 cells polarization

ST6GAL1 gene knockout can inhibit the polarization of CD4+ T cells to Th17 cells, regulate the balance of Th17 / Treg, down-regulate the IL-17 signaling pathway, inhibit the production of pro-inflammatory cytokines and promote the secretion of anti-inflammatory cytokines to reduce the symptoms of UC.