Po-05-207 immune signaling in cardiac myocytes drives injury and arrhythmias in arrhythmogenic cardiomyopathy

We reported that iPSC-cardiac myocytes from patients with arrhythmogenic cardiomyopathy (ACM) mount an innate immune response under basal conditions in vitro. In addition, blocking NFκB-innate immune signaling prevents disease in ACM mice (Dsg2mut/mut mice). Here, we defined the pathogenic roles of cardiac immune signaling vs. infiltrating inflammatory cells in Dsg2mut/mut mice.