Biomineralized nanomedicine for enhanced cancer therapy through in situ toxification and amplified Ca2+ overload

Ying Peng,Peng Liu,Jinsong Ding,Wenhu Zhou

Chemical Engineering Journal（2023）

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摘要

•DSF-Cu2+ complex synergizes with external Ca2+, causing cytoplasmic Ca2+ overload.•CuCaP@DTC releases DTC, Cu2+, Ca2+ in acidic TME, ensuring targeted drug delivery.•CuCaP@DTC induces intracellular ER stress, Ca2+ overload, mitochondrial dysfunction.•CuCaP@DTC demonstrates superior anti-tumor efficacy and high biocompatibility.

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关键词

Disulfiram,Copper,Drug repurposing,pH-responsive,Oxidative stress

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