Effect of an experimental TiF₄/NaF solution in preventing tooth erosion

Objective: This was a randomized, double-blind, parallel, placebo-controlled in vivo study investigating the protective potential of a titanium tetrafluoride/ sodium fluoride (TiF4/NaF) solution compared to its respective positive and negative controls under an in vivo model, as well as the perception of participants regarding the use of this experimental solution.Methods: After the ethics approval and the selection procedures, 33 participants were divided into three treatments: TiF4/NaF solution (500 ppm F, pH 4.4); AmF/NaF/SnCl2-mouthwash (500 ppm F, pH 4.5) and water (pH 7.0) (n = 11). After professional cleaning, the participants rinsed with one of the solutions for one minute and waited two hours for the erosive challenge. The erosive solution (1 % citric acid, pH 2.5) was applied for 10 s on each central incisor (enamel area: 4 mm(2)) and collected for calcium analysis using III Arsenazo colorimetric method. The Ca2+ release data were compared using Kruskal-Wallis/ Dunn tests (p < 0.05).Results: Teeth treated with both fluoride solutions released less calcium into the acid (median and interquartile interval: TiF4/NaF - 0.45/0.19 mM and AmF/NaF/SnCl2 - 0.46/0.15 mM Ca2+, p = 0.99) compared to the negative control (1.12/0.42 mM Ca2+, 60 % reduction, p < 0.0006). For both F solutions, only one participant per group reported unpleasant taste. Four participants belonging to AmF/NaF/SnCl2-mouthwash reported burning sensation post-rinse, while only one participant described such feeling after TiF4/NaF rinsing.Conclusion: The experimental TiF4/NaF solution was as effective as the commercial AmF/NaF/SnCl2-mouthwash in protecting enamel against erosive demineralization with a good acceptability by the participants.