737P Vascular fingerprint tool to identify testicular cancer patients at high-risk for early cardiovascular events after cisplatin-based chemotherapy

Testicular cancer (TC) patients treated with chemotherapy (CT) have an increased risk of early cardiovascular events. This study aims to validate a vascular fingerprint tool developed to identify TC patients at high-risk for such events (Lubberts, Eur J Cancer 63:180, 2016). A multicenter prospective study (NCT02573584) was performed in metastatic TC patients (IGCCCG good or intermediate risk; retroperitoneal mass <5 cm). The vascular fingerprint was assessed before start of CT and consists of 5 risk factors: smoking, overweight (BMI>25 kg/m2), hypertension (blood pressure >140/90 mmHg), dyslipidemia (fasting cholesterol >5.1 mmol/L or LDL >2.5 mmol/L) and diabetes mellitus (fasting glucose ≥ 7.0 mmol/L). Presence of ≥ 3 risk factors was defined as high-risk vascular fingerprint. A log-rank test was performed using a cardiovascular event within 1 year after start of CT as primary endpoint. 196 TC patients were included; 15 patients (7.7%) developed a cardiovascular event: [ 4 (2.0%) arterial events and 11 (5.6%) venous thrombotic events]. TC patients with a high-risk vascular fingerprint (n=62) had a higher risk of developing a cardiovascular event (HR: 3.27; 95% CI: 1.16 – 9.18; Log-rank: p=0.017). All patients with an arterial event had a high-risk vascular fingerprint compared to 5/11 patients with a venous event. Patients who developed a cardiovascular event were older (Table). Table: 737PRisk factors before start of CT in TC patients with or without cardiovascular eventsCardiovascular event (n = 15)No cardiovascular event (n = 181)Median (range) / n (%)Median (range) / n (%)P*Age at start of CT, years40 (22-50)31 (17-48)0.013SmokingOverweightHypertensionDyslipidemiaDiabetes mellitus5 (33.3)13 (86.7)7 (46.7)13 (86.7)1 (6.7)63 (34.8)107 (59.4)47 (26.6)113 (70.2)6 (3.5)0.9080.0370.1320.238 0.445Total score vascular fingerprint3 (0-4)2 (0-4)0.035High-risk vascular fingerprint9 (60.0)53 (30.5)0.041∗X2-, Fisher’s exact- or Mann-Whitney U test Open table in a new tab ∗X2-, Fisher’s exact- or Mann-Whitney U test The vascular fingerprint tool is effective in identifying TC patients at high-risk for early cardiovascular events and can be used to select TC patients for preventative strategies.