Copper-Mediated Oxidative Chloro- and Bromodifluoromethylation of Phenols
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY(2023)
摘要
The first oxidative chloro- and bromodifluoromethylation of phenols with (CH3)(3)SiCF2X and CuX (X = Cl or Br) in the presence of Selectfluor under mild reaction conditions was developed. This protocol provided a practical and efficient method for the synthesis of a diverse range of biologically valuable and synthetically challenging chloro- and bromodifluoromethyl aryl ethers. Preliminary mechanistic studies suggest that this reaction proceeded through a difluorocarbene-involved oxidative coupling process.
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