Brain-derived neurotrophic factor gene polymorphism affects cognitive function and neurofilament light chain level in patients with subcortical ischaemic vascular dementia.

Xiaojuan Yao,Guotao Yang,Tingting Fang, Zhuo Tian, Yunyao Lu, Feifan Chen,Ping Che,Jingshan Chen,Nan Zhang

Frontiers in aging neuroscience（2023）

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摘要

The rs6265 polymorphism of the BDNF gene is associated with semantic language fluency in patients with SIVD. The Met genotype may be a risk factor for cognitive impairment and neuronal injury.

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关键词

brain-derived neurotrophic factor, subcortical ischaemic vascular dementia, cognitive function, small vessel disease, neurofilament light chain, polymorphism

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