Synthesis and evaluation of highly potent HBV capsid assembly modulators (CAMs)

Franck Amblard,Zhe Chen, John Wiseman,Shaoman Zhou, Peng Liu, Mohammad Salman,Kiran Verma,Niloufar Azadi,Jessica Downs-Bowen,Sijia Tao, Amita Kumari,Qingling Zhang,David B. Smith,Dharmeshkumar Patel,Leda Bassit,Raymond F. Schinazi

Bioorganic chemistry（2023）

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摘要

•Despite numerous drugs to treat chronic hep B infections, there is no cure.•Highly potent CAMs could be used to develop novel curative approaches.•SAR around known HBV CAM GLP-26 has been performed.•Novel HBV CAM displaying sub-nanomolar activity were identified.

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关键词

Hepatitis,Antiviral,Virus,HBV capsid,Drug,Small molecules,CAM,CAE,Ritonavir

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