D-optimal mixture design inspired modified release tablet formulation of lamotrigine for the treatment of seizures: An in-depth characterization

•Lamotrigine (LTG) is an antiseizure drug suffers from poor water solubility.•Eudragit RL and Eudragit RS and PVP K-30 were employed as rate controlling polymers and solid dispersion was used as formulation technology.•D-optimal mixture design was used for the optimization of the formulation batches.•The obtained data were kept into different in vitro kinetic models, including zero and first order, Higuchi and Hixon-Crowell model.•The investigation presents an industrially applicable solution to develop novel RCT.