Large-Scale Meta-GWAS Reveals Common Genetic Factors Linked to Radiation-Induced Acute Toxicities across Cancers.

Elnaz Naderi,Miguel E Aguado-Barrera,Line M H Schack,Leila Dorling,Tim Rattay,Laura Fachal,Holly Summersgill, Laura Martínez-Calvo,Ceilidh Welsh,Tom Dudding,Yasmin Odding,Ana Varela-Pazos,Rajesh Jena,David J Thomson,Roel J H M Steenbakkers,Joe Dennis,Ramón Lobato-Busto,Jan Alsner,Andy Ness,Chris Nutting,Antonio Gómez-Caamaño,Jesper G Eriksen,Steve J Thomas,Amy M Bates,Adam J Webb,Ananya Choudhury,Barry S Rosenstein,Begona Taboada-Valladares,Carsten Herskind,David Azria,David P Dearnaley,Dirk de Ruysscher,Elena Sperk,Emma Hall,Hilary Stobart,Jenny Chang-Claude,Kim De Ruyck,Liv Veldeman,Manuel Altabas,Maria Carmen De Santis,Marie-Pierre Farcy-Jacquet,Marlon R Veldwijk,Matthew R Sydes,Matthew Parliament,Nawaid Usmani,Neil G Burnet,Petra Seibold,R Paul Symonds,Rebecca M Elliott,Renée Bultijnck,Sara Gutiérrez-Enríquez,Meritxell Mollà,Sarah L Gulliford,Sheryl Green,Tiziana Rancati,Victoria Reyes, Ana Carballo,Paula Peleteiro,Paloma Sosa-Fajardo,Chris Parker,Valérie Fonteyne,Kerstie Johnson,Maarten Lambrecht,Ben Vanneste,Riccardo Valdagni,Alexandra Giraldo,Mónica Ramos,Brenda Diergaarde,Geoffrey Liu,Suzanne M Leal,Melvin L K Chua,Miranda Pring,Jens Overgaard,Luis M Cascallar-Caneda,Fréderic Duprez,Christopher J Talbot,Gillian C Barnett,Alison M Dunning,Ana Vega,Christian Nicolaj Andreassen,Johannes A Langendijk,Catharine M L West,Behrooz Z Alizadeh,Sarah L Kerns

JNCI cancer spectrum（2023）

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摘要

There is shared SNP-based heritability for acute RIT across and within individual cancer sites. Future meta-GWAS among large radiotherapy patient cohorts are worthwhile to identify the common causal variants for acute radiotoxicity across cancer types.

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