Ventricular CSF proteomic profiles and predictors of surgical treatment outcome in chronic hydrocephalus.

Nina Rostgaard,Markus Harboe Olsen,Sara Diana Lolansen,Nicolas Hernandez Nørager,Peter Plomgaard,Nanna MacAulay,Marianne Juhler

Acta neurochirurgica（2023）

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摘要

Here, we show that the proteomic profile of ventricular CSF from patients with hydrocephalus differs slightly from control subjects. Furthermore, we find ten predictors of response to surgical outcome (endoscopic third ventriculostomy or ventriculo-peritoneal shunt) in patients with obstructive hydrocephalus.

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关键词

Obstructive hydrocephalus, Idiopathic normal pressure hydrocephalus, Cerebrospinal fluid, Biomarkers, Proteomic profile, Predictors, Mass spectrometry, Proteomics

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