Hematopoietic memory of severe COVID-19 infection

A new study describes that individuals who recovered from severe coronavirus disease-19 (COVID-19) exhibit long-term epigenetic changes in their hematopoietic stem and progenitor cells, which are subsequently conveyed to circulating progeny myeloid cells. This epigenetic memory of hematopoietic cells is partly mediated by IL-6 induction in the acute phase of the infection and may account for the long-term altered myeloid cell function after COVID-19.