miRNA transcriptomics analysis shows miR-483-5p and miR-503-5p targeted miRNA in extracellular vesicles from severe acute pancreatitis-associated lung injury patients

Yicheng Xiong, Xiangyang Chen,Xiaodan Yang, Hang Zhang,Xinmiao Li,Zilu Wang, Sizhe Feng, Wen Wen,Xiangqing Xiong

International Immunopharmacology（2023）

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摘要

•Clinical samples was used for miRNA sequencing, statistical analysis.•We identified the regulatory network via miR-503-5p-UNC5B for severe acute pancreatitis-associated lung injury.•miR-503-5p might influence inflammatory response and oxidative stress in the lung injury via affecting UNC5B.

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关键词

Severe acute pancreatitis-associated lung injury (SAPALI),MicroRNA transcriptomics,miRNA–mRNA interaction,Protein-protein interaction (PPI),Extracellular vesicles

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