Quantification of pyruvate in-vitro using mid-infrared spectroscopy: Developing a system for microdialysis monitoring in traumatic brain injury patients

Chisomo Zimphango,Farah C. Alimagham,Tanya Hutter,Peter J. Hutchinson,Keri L.H. Carpenter

Brain and Spine（2023）

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摘要

•We have demonstrated the capability of a mid-infrared spectroscopic system to quantify pyruvate (an important marker for brain's redox state in TBI) down to concentrations as low as 0.07 mM, a clinically recognised threshold.

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microdialysis monitoring,pyruvate,traumatic brain injury,in-vitro,mid-infrared

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