Selective BET inhibitor RVX-208 ameliorates periodontal inflammation and bone loss.

Mingxu Sun,Nicholas Clayton, Sheikh Alam,Niels Asmussen, Andrew Wong, Jin Ha Kim,Gary Luong, Sasan Mokhtari, David Pellei,Caroline K Carrico,Zvi Schwartz,Barbara D Boyan,William V Giannobile,Sinem Esra Sahingur,Zhao Lin

Journal of clinical periodontology（2023）

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摘要

RVX-208 regulated both upstream (inflammatory cytokine production) and downstream (osteoclast differentiation) events that lead to periodontal tissue destruction, suggesting that it may be a promising 'epi-drug' for the prevention of periodontitis.

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关键词

BET inhibitor, histone acetylation, osteoclast, periodontitis, RVX-208

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