Cellular Heterogeneity of Activated Primary Human Macrophages and Associated Drug-Gene Networks: From Biology to Precision Therapeutics.

Julius L Decano,Enrico Maiorino,Joan T Matamalas,Sarvesh Chelvanambi,Bart M Tiemeijer,Yoshihiro Yanagihara,Shin Mukai,Prabhash Kumar Jha,Diego V S Pestana,Edwin D'Souza,Mary Whelan,Rile Ge,Takaharu Asano,Amitabh Sharma,Peter Libby,Sasha A Singh,Elena Aikawa,Masanori Aikawa

Circulation（2023）

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摘要

We characterized 2 clusters of macrophages in atherosclerosis and combined our cellular data with a cell-signature drug library to identify a novel compound that targets a subset of macrophages in atherosclerosis. Our approach is a precision medicine strategy to identify new drugs that target atherosclerosis and other inflammatory diseases.

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