Sphingolipid Signaling Takes Center Stage in Regulation of Lymphatic-Immune Crosstalk in Lymphedema.

HomeCirculationVol. 148, No. 16Sphingolipid Signaling Takes Center Stage in Regulation of Lymphatic–Immune Crosstalk in Lymphedema No AccessEditorialRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessEditorialRequest AccessFull TextSphingolipid Signaling Takes Center Stage in Regulation of Lymphatic–Immune Crosstalk in Lymphedema Ebba Brakenhielm Ebba BrakenhielmEbba Brakenhielm Correspondence to: Ebba Brakenhielm, Inserm UMR1096, Normandy University, UniRouen, Faculty of Medicine, 22 Boulevard Gambetta, Rouen, France. Email E-mail Address: [email protected] https://orcid.org/0000-0003-3378-8300 Rouen Institute for Innovation and Research in Biomedicine, INSERM EnVI UMR1096, University of Rouen Normandy, France. Search for more papers by this author Originally published16 Oct 2023https://doi.org/10.1161/CIRCULATIONAHA.123.066578Circulation. 2023;148:1250–1253This article is a commentary on the followingAbnormal Lymphatic Sphingosine-1-Phosphate Signaling Aggravates Lymphatic Dysfunction and Tissue InflammationFootnotesThe opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.For Disclosures, see page 1253.Circulation is available at www.ahajournals.org/journal/circCorrespondence to: Ebba Brakenhielm, Inserm UMR1096, Normandy University, UniRouen, Faculty of Medicine, 22 Boulevard Gambetta, Rouen, France. Email Ebba.Brakenhielm@inserm.frREFERENCES1. Brakenhielm E, Alitalo K. Cardiac lymphatics in health and disease.Nat Rev Cardiol. 2019; 16:56–68. doi: 10.1038/s41569-018-0087-8CrossrefMedlineGoogle Scholar2. Oliver G, Kipnis J, Randolph GJ, Harvey NL. The lymphatic vasculature in the 21st century: novel functional roles in homeostasis and disease.Cell. 2020; 182:270–296. doi: 10.1016/j.cell.2020.06.039CrossrefMedlineGoogle Scholar3. Oliver G, Detmar M. The rediscovery of the lymphatic system: old and new insights into the development and biological function of the lymphatic vasculature.Genes Dev. 2002; 16:773–783. doi: 10.1101/gad.975002CrossrefMedlineGoogle Scholar4. Rockson SG. Lymphedema after breast cancer treatment.N Engl J Med. 2018; 379:1937–1944. doi: 10.1056/NEJMcp1803290CrossrefMedlineGoogle Scholar5. Zampell JC, Yan A, Elhadad S, Avraham T, Weitman E, Mehrara BJ. CD4+ cells regulate fibrosis and lymphangiogenesis in response to lymphatic fluid stasis.PLoS One. 2012; 7:e49940. doi: 10.1371/journal.pone.0049940CrossrefMedlineGoogle Scholar6. Randolph GJ, Ivanov S, Zinselmeyer BH, Scallan JP. The lymphatic system: integral roles in immunity.Annu Rev Immunol. 2017; 35:31–52. doi: 10.1146/annurev-immunol-041015-055354CrossrefMedlineGoogle Scholar7. Shin K, Kataru RP, Park HJ, Kwon B-I, Kim TW, Hong YK, Lee S-H. TH2 cells and their cytokines regulate formation and function of lymphatic vessels.Nat Commun. 2015; 6:6196. doi: 10.1038/ncomms7196CrossrefMedlineGoogle Scholar8. García Nores GD, Ly CL, Cuzzone DA, Kataru RP, Hespe GE, Torrisi JS, Huang JJ, Gardenier JC, Savetsky IL, Nitti MD, et al. CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema.Nat Commun. 2018; 9:1970. doi: 10.1038/s41467-018-04418-yCrossrefMedlineGoogle Scholar9. Gousopoulos E, Proulx ST, Bachmann SB, Scholl J, Dionyssiou D, Demiri E, Halin C, Dieterich LC, Detmar M. Regulatory T cell transfer ameliorates lymphedema and promotes lymphatic vessel function.JCI Insight. 2016; 1:e89081. doi: 10.1172/jci.insight.89081CrossrefMedlineGoogle Scholar10. Rockson SG. Advances in lymphedema.Circ Res. 2021; 128:2003–2016. doi: 10.1161/CIRCRESAHA.121.318307LinkGoogle Scholar11. Kim D, Tian W, Wu TT-H, Xiang M, Vinh R, Chang JL, Gu S, Lee S, Zhu Y, Guan T, et al. Abnormal lymphatic sphingosine-1-phosphate signaling aggravates lymphatic dysfunction and tissue inflammation.Circulation. 2023:148:1231–1249. doi: 10.1161/CIRCULATIONAHA.123.064181LinkGoogle Scholar12. Rockson SG, Tian W, Jiang X, Kuznetsova T, Haddad F, Zampell J, Mehrara B, Sampson JP, Roche L, Kim J, et al. Pilot studies demonstrate the potential benefits of antiinflammatory therapy in human lymphedema.JCI Insight. 2018; 3:e123775. doi: 10.1172/jci.insight.123775CrossrefMedlineGoogle Scholar13. Weigel C, Bellaci J, Spiegel S. Sphingosine-1-phosphate and its receptors in vascular endothelial and lymphatic barrier function.J Biol Chem. 2023; 299:104775. doi: 10.1016/j.jbc.2023.104775CrossrefMedlineGoogle Scholar14. Houssari M, Dumesnil A, Tardif V, Kivelä R, Pizzinat N, Boukhalfa I, Godefroy D, Schapman D, Hemanthakumar KA, Bizou M, et al. Lymphatic and immune cell cross-talk regulates cardiac recovery after experimental myocardial infarction.Arterioscler Thromb Vasc Biol. 2020; 40:1722–1737. doi: 10.1161/ATVBAHA.120.314370LinkGoogle Scholar15. Mehrara BJ, Park HJ, Kataru RP, Bromberg J, Coriddi M, Baik JE, Shin J, Li C, Cavalli MR, Encarnacion EM, et al. Pilot study of anti-Th2 immunotherapy for the treatment of breast cancer-related upper extremity lymphedema.Biology. 2021; 10:934. doi: 10.3390/biology10090934CrossrefMedlineGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. 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Circulation. 2023;148:1231-1249 October 17, 2023Vol 148, Issue 16 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.123.066578PMID: 37844150 Originally publishedOctober 16, 2023 KeywordsT-lymphocyteslymphedemacytokinesendothelial cellsEditorialsinflammationPDF download Advertisement SubjectsEndothelium/Vascular Type/Nitric OxideInflammationLipids and CholesterolTranslational StudiesVascular Disease