Investigating specificity and sex-dependent manifestation of polygenic risk in a child clinical cohort

Alysa E. Doyle,Pieter J. Vuijk,Giulio Genovese,Tian Ge, Michael R. Capawana, Sonia L. Tremblay, Sarah L. O'Dor,Ellen B. Braaten,Joanna Martin

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY（2023）

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摘要

Understanding the potential value of polygenic risk scores (PRSs) for child and adolescent psychiatry requires further investigation of how PRSs perform in cohorts of referred youth. We addressed 2 knowledge gaps relevant to clinical translation, that is, specificity and sex-dependent manifestation, in relation to PRS for ADHD, anxiety (ANX), and depression (MDD) in child and adolescent psychiatric outpatients.

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