Leveraging the genetics of adhd symptom dimensions in child psychiatric outpatients

Polygenic risk scores (PRSs) based on specific symptom dimensions hold potential to index distinct components of complex neuropsychiatric conditions. This possibility is particularly relevant to ADHD, because clinically referred youth can vary substantially in their levels of inattention and hyperactivity/impulsivity symptoms. We aimed to understand the relationship between PRSs based on inattention and hyperactive/impulsivity symptoms and related phenotypes in child and adolescent psychiatry outpatients. Such work is a necessary first step toward understanding whether symptom-based PRSs could serve as objective indicators of risk and tools for risk stratification in clinical settings.