Functional ingredients of Folium Nelumbinis against amyloid-β toxicity in C. elegans: The bioactive compounds screened and the molecular mechanism explored

•Folium Nelumbinis extracted fraction significantly delayed Aβ-induced paralysis in CL4176 while inhibiting AChE activity.•The extracted fraction reduced oxidative stress induced by H2O2 and heat in the wild strain.•Effects were mainly mediated by DAF-16/FOXO signaling pathway and ACE1/ACE2 axis.•Five flavonoids from the extracted fraction were identified and verified as AChE inhibitors.