Tirapazamine combined with photodynamic therapy improves the efficacy of ABZSO nanoparticles on Echinococcosis granulosus via further enhancing “breaking-then-curing”

Yuehong Gong,Tianjiao Zhou,Wusimanjiang Aimaiti, Yuxia Lin,Yuan Xu,Jianhua Yang,Zhangjian Huang,Hao Wen,Hulin Jiang,Jianhua Wang

Journal of Photochemistry and Photobiology B: Biology（2023）

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摘要

•ABZSO NPs combined with TPZ and PDT has a better inhibitory effect on the growth of Egs in CE.•PDT could firstly break the wall of Egs (breaking) to further promote the infiltration of ABZSO NPs into Egs (curing).•TPZ could be activated by PDT, which collaborated with ABZSO NPs to further promote the death of Egs.•The combined therapy may be used in CE clinical treatment via further enhancing the strategy of “breaking-then-curing”.

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关键词

Cystic Echinococcosis,Echinococcus granulosus,Breaking-then-curing,Photodynamic therapy,ABZSO NPs

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