Low microsatellite instability: A distinct instability type in gastric cancer?

Meike Kohlruss,Shounak Chakraborty, Alexander Hapfelmeier,Moritz Jesinghaus,Julia Slotta-Huspenina,Alexander Novotny,Leila Sisic,Matthias M Gaida,Katja Ott,Wilko Weichert,Nicole Pfarr,Gisela Keller

Journal of cancer research and clinical oncology（2023）

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摘要

MSI-L due to instability at dinucleotide repeat markers was associated with increased TMB after neoadjuvant CTx treatment, indicating sensitivity to platinum/5-FU CTx. If confirmed in further studies, this could contribute to refined chemotherapeutic options including immune-based strategies for GC patients with MSI-L tumors.

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关键词

Adenocarcinoma,Gastric,Microsatellite instability,Neoadjuvant chemotherapy,Tumor mutation burden

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