Zinc-sensitive MRI contrast agents: importance of local probe accumulation in zinc-rich tissues.

Kyangwi P Malikidogo,Manon Isaac, Adrien Uguen,Sandra Même,Agnès Pallier, Rudy Clémençon,Jean-François Morfin,Sara Lacerda,Éva Tóth,Célia S Bonnet

Chemical communications (Cambridge, England)（2023）

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摘要

We present the characterisation of a Gd-based contrast agent that responds to Zn upon interaction with Human Serum Albumin. We show that the contradictory behaviour is related to Gd-accumulation in Zn-rich tissues. This highlights the importance of the biodistribution of such contrast agents.

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关键词

mri,local probe accumulation,zinc-sensitive,zinc-rich

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