An efficient organopromotor L-arginine facilitated synthesis of thiazolo[3,2-a]pyrimidine derivatives in EtOH:H₂O solvent

An efficient, one pot, multicomponent, L-arginine catalyzed synthesis of thiazolo[3,2-a]pyrimidines is described. L-arginine is an easily available, biodegradable, inexpensive, promising bio-organic molecule. The current strategy is the first example of amino acid promoted, green synthesis of a series of thiazolo[3,2-a]pyrimidines via the formation of C-N and C-C bonds. The major advantages of the present methodology such as recyclability of catalyst, operational simplicity, easy scale-up, wide substrate scope, easy work-up, inexpensive, excellent yields, and high atom economy make it a distinct improvement over the prevailing strategies.