MicroRNA-532 Promotes Proliferation, Metastasis and Autophagy in Esophageal Cancer via Targeting Naked Cuticle 1

The aim of this study was to elucidate the role of microRNA-532 in influencing the progression of esophageal cancer and cell autophagy through negatively regulating Naked cuticle 1 (NKD1) level. Relative levels of microRNA-532 and NKD1 in esophageal cancer tissues and corresponding paracancerous ones were detected. The relationship between microRNA532 level and overall survival in esophageal cancer patients was statistically analyzed. Subsequently, regulatory effects of microRNA-532 and NKD1 on viability, metastasis and autophagy in TE-1 and EC-109 cells were examined. The interaction between microRNA-532 and NKD1 was finally explored. MicroRNA-532 was upregulated in esophageal cancer tissues and its high level indicated poor prognosis in esophageal cancer patients. Serving as the downstream gene binding microRNA-532, NKD1 level was IP:negatively203.8.109.20regulated byOn: Fri,microRNA-532.07 Jul 2023Knockdown10:32:56ofmicroRNA-532 weakened viability and metastasis, as well as downregulated autopagy-assoiated ges (Atg5, LC-3I and LC-3II) in TE-1 and EC-109 cells. Copyright: American Scientifc Publshers Knockdown of NKD1 achieved the opposite results. MicroRNA-532 promotes proliferation, metastasis and autophagy in Delivered by Ingenta esophageal cancer by downregulating NKD1. It is believed that microRNA-532 may be a promising therapeutic target for esophageal cancer.