Engineering prodrug nanoparticles for targeted therapy in heterogeneous glioblastoma

Xuefeng Zhang,Qing Guo,Zongren Zhao,Peng Cheng,Anhua Wu,Hongmei Liu

CHEMICAL ENGINEERING JOURNAL（2023）

引用 0|浏览4

暂无评分

摘要

•Glioblastoma microenvironment heterogeneity poses a major challenge to its therapy.•A-PER-p(TMZ)29/Clo contained perifosine, poly-temozolomide prodrug, and clodronate.•A-PER-p(TMZ)29/Clo can deplete tumor-associated macrophages.•A-PER-p(TMZ)29/Clo can eradicate glioma stem cells.•A-PER-p(TMZ)29/Clo can inhibit glioblastoma activation.

查看译文

关键词

Glioblastoma,Heterogeneity,Akt inhibitors,Glioma stem cells,Tumor-associated macrophages

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要