Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations.

Kangcheng Hou,Stephanie Gogarten,Joohyun Kim,Xing Hua, Julie-Alexia Dias,Quan Sun,Ying Wang,Taotao Tan, Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium Methods Working Group,Elizabeth G Atkinson,Alicia Martin,Jonathan Shortt,Jibril Hirbo,Yun Li,Bogdan Pasaniuc,Haoyu Zhang

bioRxiv : the preprint server for biology(2023)

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摘要
Admixed populations, with their unique and diverse genetic backgrounds, are often underrepresented in genetic studies. This oversight not only limits our understanding but also exacerbates existing health disparities. One major barrier has been the lack of efficient tools tailored for the special challenges of genetic study of admixed populations. Here, we present admix-kit, an integrated toolkit and pipeline for genetic analyses of admixed populations. Admix-kit implements a suite of methods to facilitate genotype and phenotype simulation, association testing, genetic architecture inference, and polygenic scoring in admixed populations.
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genetic analyses,admix-kit
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