BAllC and BAllCools: Efficient Formatting and Operating for Single-Cell DNA Methylation Data

Wei Tian,Wubin Ding, Jiawei Shen, Daofeng Li, Ting Wang,Joseph R Ecker

biorxiv(2024)

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摘要
Motivation: With single-cell DNA methylation studies yielding vast datasets, existing data formats struggle with the unique challenges of storage and efficient operations, highlighting a need for improved solutions. Results: BAllC (Binary All Cytosines) emerges as a tailored binary format for methylation data, addressing these challenges. BAllCools, its complementary software toolkit, enhances parsing, indexing, and querying capabilities, promising superior operational speeds and reduced storage needs. Availability: https://github.com/jksr/ballcools ### Competing Interest Statement J.R.E is a member of the scientific advisor for Zymo Research In. and Ionis Pharmaceuticals.
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