Effectiveness of a Messenger RNA Vaccine Booster Dose Against Coronavirus Disease 2019 Among US Healthcare Personnel, October 2021-July 2022.

Ian D Plumb,Nicholas M Mohr, Melissa Hagen, Ryan Wiegand,Ghinwa Dumyati,Karisa K Harland,Anusha Krishnadasan, Jade James Gist,Glen Abedi,Katherine E Fleming-Dutra,Nora Chea,Jane Lee,Devra Barter,Monica Brackney,Scott K Fridkin,Lucy E Wilson, Sara A Lovett,Valerie Ocampo,Erin C Phipps, Tiffanie M Marcus,Howard A Smithline,Peter C Hou,Lilly C Lee,Gregory J Moran,Elizabeth Krebs,Mark T Steele,Stephen C Lim,Walter A Schrading,Brian Chinnock,David G Beiser,Brett Faine,John P Haran,Utsav Nandi, Anne K Chipman,Frank LoVecchio,David A Talan,Tamara Pilishvili

Open forum infectious diseases（2023）

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摘要

A booster dose conferred substantial protection against COVID-19 among healthcare personnel. However, VE was lower during Omicron predominance, and waning effectiveness was observed 4 months after booster dose receipt during this period. Our findings support recommendations to stay up to date on recommended doses of COVID-19 vaccines for all those eligible.

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COVID-19, SARS-CoV-2, vaccine effectiveness, Omicron, healthcare personnel

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