Targeting BRD4 attenuates the stemness and aggressiveness of ameloblastoma.

Jiaxiang Xie, Jingqi Zhang,Gan Xiong,Shengqi Ouyang,Bokai Yun,Xiuyun Xu,Wenjin Wang,Ming Zhang,Nan Xie,Demeng Chen,Cheng Wang

Oral diseases（2023）

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摘要

BRD4 increases the aggressiveness and promotes the recurrence of ameloblastoma by regulating the Wnt pathway and stemness-associated pathways. These findings highlight BRD4 as a promising therapeutic target in AM management.

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关键词

ameloblastoma, BRD4, tumorigenesis, Wnt pathway

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