Eosinophil-derived neurotoxin levels in early childhood and association with preschool asthma - A prospective observational study.

Martin Färdig,Anine Lie,Magnus P Borres,Tina Ekenkrantz,Berit Granum,Guttorm Haugen,Christine M Jonassen,Robert Movérare,Eva Maria Rehbinder,Håvard O Skjerven, Anne Cathrine,Riyas Vettukattil,Karin C Lødrup Carlsen,Cilla Söderhäll,Björn Nordlund

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology（2023）

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摘要

We report EDN values in early childhood, demonstrating higher levels at 1 compared to 3 years and in boys compared to girls at both ages. Higher EDN levels at both ages were associated with preschool asthma. However, EDN cut-off levels for preschool asthma were overall lower than the ULN of non-atopic children, limiting translation into clinical practice.

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关键词

asthma, child, eosinophil-derived neurotoxin, PreventADALL, sex, type 2 inflammation, wheeze

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