Metformin targets intestinal immune system signaling pathways in a high-fat diet-induced mouse model of obesity and insulin resistance.

Monta Brīvība,Laila Silamiķele,Ineta Kalniņa,Ivars Silamiķelis,Līga Birzniece,Laura Ansone,Lauma Jagare,Ilze Elbere,Jānis Kloviņš

Frontiers in endocrinology（2023）

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摘要

Our study supports the immunomodulatory effect of metformin in the ileum of obese and insulin-resistant C57BL/6N mice contributed by intestinal immunoglobulin responses, with a prominent emphasis on the downregulation of NF-kappa B signaling pathway, associated with alterations in the composition of the gut microbiome.

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metformin, NF-kappa B signaling, humoral immune responses, high-fat diet, intestinal transcriptome

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