Bone marrow granulomatous reaction to silicone from breast implants

Silicone lymphadenopathy occurs following migration of silicone particles through the lymphatic system to regional nodes and more distal extranodal sites as a consequence of implant rupture or “gel bleed”. This silicone migration and tissue deposition with granulomatous reaction may cause systemic symptoms which can mimic lymphoma – fatigue, fever, and sweats. It is an important condition to be aware of and to consider in the context of bone marrow granulomatosis. The authors declare no conflicts of interest.