Dynamic changes of left atrial substrate over time following pulmonary vein isolation: The Progress-AF study.

Lorenzo Marcon,Marco Bergonti,Francesco Spera,Johan Saenen,Wim Huybrechts,Hielko Miljoen,Olivier Van Leuven,Lien Vandaele,Anouk Wittock,Hein Heidbuchel,Andrea Sarkozy

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology（2023）

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摘要

Our study describes bidirectional dynamic properties of the LA substrate with concordant either progressive or regressive changes. Regression occurs with reduced AF burden after the first procedure while progression is associated with persistent AF recurrence despite durable PV isolation. The dynamic nature of LA substrate poses questions about LVZ based ablation strategies.

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